Takahiro Inoue - Effects of exercise and pharmacological inhibition of

Journal article

H. Maejima, Mika Kitahara, Y. Takamatsu, Hiroki Mani, Takahiro Inoue
Brain Research, 2020

Cite

APA Click to copy
Maejima, H., Kitahara, M., Takamatsu, Y., Mani, H., & Inoue, T. (2020). Effects of exercise and pharmacological inhibition of histone deacetylases (HDACs) on epigenetic regulations and gene expressions crucial for neuronal plasticity in the motor cortex. Brain Research.

Chicago/Turabian Click to copy
Maejima, H., Mika Kitahara, Y. Takamatsu, Hiroki Mani, and Takahiro Inoue. “Effects of Exercise and Pharmacological Inhibition of Histone Deacetylases (HDACs) on Epigenetic Regulations and Gene Expressions Crucial for Neuronal Plasticity in the Motor Cortex.” Brain Research (2020).

MLA Click to copy
Maejima, H., et al. “Effects of Exercise and Pharmacological Inhibition of Histone Deacetylases (HDACs) on Epigenetic Regulations and Gene Expressions Crucial for Neuronal Plasticity in the Motor Cortex.” Brain Research, 2020.

BibTeX Click to copy

@article{h2020a,
  title = {Effects of exercise and pharmacological inhibition of histone deacetylases (HDACs) on epigenetic regulations and gene expressions crucial for neuronal plasticity in the motor cortex.},
  year = {2020},
  journal = {Brain Research},
  author = {Maejima, H. and Kitahara, Mika and Takamatsu, Y. and Mani, Hiroki and Inoue, Takahiro}
}

Abstract

The objective of this study was to examine the effect of epigenetic treatment using an histone deacetylases (HDAC) inhibitor in addition to aerobic exercise on the epigenetic markers and neurotrophic gene expressions in the motor cortex, to find a more enriched brain pre-conditioning for motor learning in neurorehabilitation. ICR mice were divided into four groups based on two factors: HDAC inhibition and exercise. Intraperitoneal administration of an HDAC inhibitor (1.2 g/kg sodium butyrate, NaB) and treadmill exercise (approximately at 10 m/min for 60 min) were conducted five days a week for four weeks. NaB administration inhibited total HDAC activity and enhanced acetylation level of histones specifically in histone H4, accompanying the increase of transcription levels of immediate-early genes (IEGs) (c-fos and Arc) and neurotrophins (BDNF and NT-4) crucial for neuroplasticity in the motor cortex. However, exercise enhanced HDAC activity and acetylation level of histone H4 and H3 without the modification of transcription levels. In addition, there were no synergic effects between HDAC inhibition and the exercise regime on the gene expressions. This study showed that HDAC inhibition could present more enriched condition for neuroplasticity to the motor cortex. However, exercise-induced neurotrophic gene expressions could depend on exercise regimen based on the intensity, the term etc. Therefore, this study has a novelty suggesting that pharmacological HDAC inhibition could be an alternative potent approach to present a neuronal platform with enriched neuroplasticity for motor learning and motor recovery, however, an appropriate exercise regimen is expected in this approach.